PUBLICATIONS

The class I myosin Myo1e regulates TLR4-triggered macrophage spreading, chemokine release and antigen presentation via MHC class II. J. Wenzel, J.L. Ouderkirk, M. Krendel, R. Lang. Eur J Immunol. 45:225-37, 2015. PDF

 

Non-muscle myosins in tumor progression, cancer cell invasion and metastasis. J.L. Ouderkirk, M. Krendel. Cytoskeleton, 71:447-63, 2014. PDF

 

Myosin 1e is a component of the invadosome core that contributes to regulation of invadosome dynamics.

Ouderkirk JL, Krendel M.

Exp Cell Res. 2014 Apr 1;322(2):265-76. PDF

 

Visualization of cytoskeletal dynamics in podocytes using adenoviral vectors.

Bi J, Pellenz CD, Krendel M.

Cytoskeleton. 2014 Mar;71(3):145-56. PDF

 

Myosin 1e is a component of the glomerular slit diaphragm complex that regulates actin reorganization during cell-cell contact formation in podocytes.

Bi J, Chase SE, Pellenz CD, Kurihara H, Fanning AS, Krendel M.

Am J Physiol Renal Physiol. 2013 Aug 15;305(4):F532-44. PDF

 

Podocyte-specific knockout of myosin 1e disrupts glomerular filtration. PDF

Chase SE, Encina CV, Stolzenburg LR, Tatum AH, Holzman LB, Krendel M. Am J Physiol Renal Physiol. 2012 Oct;303(7):F1099-106.

 

MYO1E Mutations and Childhood Familial Focal Segmental Glomerulosclerosis.

Mele C, Iatropoulos P, Donadelli R, Calabria A, Maranta R, Cassis P, Buelli S, Tomasoni S, Piras R, Krendel M, Bettoni S, Morigi M, Delledonne M, Pecoraro C, Abbate I, Capobianchi MR, Hildebrandt F, Otto E, Schaefer F, Macciardi F, Ozaltin F, Emre S, Ibsirlioglu T, Benigni A, Remuzzi G, Noris M. N Engl J Med. 2011 Jul 28;365(4):295-306.

 

Myo1e binds anionic phospholipids with high affinity.

E.A. Feeser, C.M. Ignacio, M. Krendel, and E.M. Ostap. Biochemistry, 49:9353-60, 2010.

 

Disruption of Myosin 1e promotes podocyte injury.

M. Krendel, S.V.Kim, T. Willinger, T. Wang, M. Kashgarian, R.A. Flavell, and M.S. Mooseker. JASN, 20:86-94, 2009.

 

Human myosin 1e tail but not motor domain replaces fission yeast Myo1 domains to support myosin-I function during endocytosis.

S.R. Barger, M.L. James, C.D.  Pellenz, M. Krendel, V. Sirotkin. Exp Cell Res. 384(2):111625, 2019. PDF

  

Squeezing in a Meal: Myosin Functions in Phagocytosis.

S.R. Barger, N.C. Gauthier, M. Krendel. Trends Cell Biol. 30(2):157-167, 2020. PDF

Membrane-cytoskeleton mechanical feedback mediated by myosin-I controls phagocytic efficiency. S. R. Barger, N. S. Reilly, M. S. Shutova, Q. Li, P. Maiuri, M.S. Mooseker, R. A. Flavell, T. Svitkina, P. W. Oakes, M. Krendel, N. Gauthier.  Nature Communications, 10(1):1249, 2019. PDF

 

Tail domains of myosin-1e regulate phosphatidylinositol signaling and F-actin polymerization at the ventral layer of podosomes. Y. Zhang, F. Cao, Y. Zhou, Z. Feng, B. Sit, M. Krendel, C. Yu. MBoC. 30(5):622-635, 2019.

 

Myosin-1E interacts with FAK proline rich region 1 to induce fibronectin-type matrix. J. B. Heim, E.J. Squirewell, A. Neu, G. Zocher, S. Sominidi-Damodaran, S.P. Wyles, E. Nikolova, N. Behrendt, D.M. Saunte, J. Lock-Andersen, K.S. Gaonkar, H. Yan, J.N. Sarkaria, M. Krendel, J. van Deursen, R. Sprangers, T. Stehle, R.T. Böttcher, J. Lee, T. Ordog, A. Meves.  Proc Natl Acad Sci U S A. 114(15):3933-3938, 2017. PDF

 

Hic-5 remodeling of the stromal matrix promotes breast tumor progression. G.J. Goreczny, J.L. Ouderkirk-Pecone, E.C. Olson, M. Krendel, C.E. Turner. Oncogene. 36(19):2693-2703, 2017.

 

Three-dimensional electron microscopy reveals the evolution of glomerular barrier injury. M.J. Randles, S. Collinson, T. Starborg, A. Mironov, M. Krendel, E. Königshausen, L. Sellin, I.S. Roberts, K.E. Kadler, J.H. Miner, R. Lennon. Sci Rep. 2016 Oct 11;6:35068. doi: 10.1038/srep35068.

 

Myosin 1e promotes breast cancer malignancy by enhancing tumor cell proliferation and stimulating tumor cell differentiation. J.L. Ouderkirk-Pecone, G.J. Goreczny, S.E. Chase, A.H. Tatum, C.E. Turner, M. Krendel. Oncotarget.7(29):46419-46432, 2016. PDF

 

Effects of FSGS-associated mutations on the stability and function of myosin-1 in fission yeast. PDF J. Bi, R.T. Carroll, M.L. James, J.L. Ouderkirk, M. Krendel, V. Sirotkin. Dis Model Mech. 8:891-902, 2015.