PUBLICATIONS
Hic-5 remodeling of the stromal matrix promotes breast tumor progression. G.J. Goreczny, J.L. Ouderkirk-Pecone, E.C. Olson, M. Krendel, C.E. Turner. Oncogene. 36(19):2693-2703, 2017.
Three-dimensional electron microscopy reveals the evolution of glomerular barrier injury. M.J. Randles, S. Collinson, T. Starborg, A. Mironov, M. Krendel, E. Königshausen, L. Sellin, I.S. Roberts, K.E. Kadler, J.H. Miner, R. Lennon. Sci Rep. 2016 Oct 11;6:35068. doi: 10.1038/srep35068.
Myosin 1e promotes breast cancer malignancy by enhancing tumor cell proliferation and stimulating tumor cell differentiation. J.L. Ouderkirk-Pecone, G.J. Goreczny, S.E. Chase, A.H. Tatum, C.E. Turner, M. Krendel. Oncotarget.7(29):46419-46432, 2016. PDF
Effects of FSGS-associated mutations on the stability and function of myosin-1 in fission yeast. PDF J. Bi, R.T. Carroll, M.L. James, J.L. Ouderkirk, M. Krendel, V. Sirotkin. Dis Model Mech. 8:891-902, 2015.
The class I myosin Myo1e regulates TLR4-triggered macrophage spreading, chemokine release and antigen presentation via MHC class II. J. Wenzel, J.L. Ouderkirk, M. Krendel, R. Lang. Eur J Immunol. 45:225-37, 2015. PDF
Non-muscle myosins in tumor progression, cancer cell invasion and metastasis. J.L. Ouderkirk, M. Krendel. Cytoskeleton, 71:447-63, 2014. PDF
Myosin 1e is a component of the invadosome core that contributes to regulation of invadosome dynamics.
Ouderkirk JL, Krendel M.
Exp Cell Res. 2014 Apr 1;322(2):265-76. PDF
Visualization of cytoskeletal dynamics in podocytes using adenoviral vectors.
Bi J, Pellenz CD, Krendel M.
Cytoskeleton. 2014 Mar;71(3):145-56. PDF
Myosin 1e is a component of the glomerular slit diaphragm complex that regulates actin reorganization during cell-cell contact formation in podocytes.
Bi J, Chase SE, Pellenz CD, Kurihara H, Fanning AS, Krendel M.
Am J Physiol Renal Physiol. 2013 Aug 15;305(4):F532-44. PDF
Podocyte-specific knockout of myosin 1e disrupts glomerular filtration. PDF
Chase SE, Encina CV, Stolzenburg LR, Tatum AH, Holzman LB, Krendel M. Am J Physiol Renal Physiol. 2012 Oct;303(7):F1099-106.
MYO1E Mutations and Childhood Familial Focal Segmental Glomerulosclerosis.
Mele C, Iatropoulos P, Donadelli R, Calabria A, Maranta R, Cassis P, Buelli S, Tomasoni S, Piras R, Krendel M, Bettoni S, Morigi M, Delledonne M, Pecoraro C, Abbate I, Capobianchi MR, Hildebrandt F, Otto E, Schaefer F, Macciardi F, Ozaltin F, Emre S, Ibsirlioglu T, Benigni A, Remuzzi G, Noris M. N Engl J Med. 2011 Jul 28;365(4):295-306.
Theoretical model of efficient phagocytosis driven by curved membrane proteins and active cytoskeleton forces. R.K. Sadhu, S.R. Barger, S. Penič., A. Iglič, M. Krendel, N.C. Gauthier, N.S. Gov. Soft Matter, 2022. doi: 10.1039/d2sm01152b. PDF
Steroid-resistant Nephrotic Syndrome-Associated MYO1E Mutations have Differential Effects on Myosin 1e Localization, Dynamics, and Activity. P-J. Liu, L.K. Gunther, M.E. Garone, C. Zhang, D. Perez, J. Bi-Karchin, C.D. Pellenz, S.E. Chase, M.F. Presti*, E.L. Plante, C.E. Martin, S. Lovric, C.M. Yengo, F. Hildebrandt, M. Krendel. JASN, 33(11), 1989–2007, 2022. PDF
F-actin Organization and Target Constriction during Primary Macrophage Phagocytosis is Balanced by Competing Activity of Myosin-I and Myosin-II. S.R. Barger, D. Vorselen, N. C. Gauthier, J. A. Theriot, M. Krendel. Mol. Biol. of the Cell, 33(14):br24, 2022. PDF
Complementary Nck1/2 Signaling in Podocytes Controls α Actinin-4-Mediated Actin Organization, Adhesion, and Basement Membrane Composition. C.E. Martin, N.J. Phippen, A. Keyvani Chahi, M. Tilak, S.L. Banerjee, P. Lu, L.A. New, C.R. Williamson, M.J. Platt, J.A. Simpson, M. Krendel, N. Bisson, A.C. Gingras, N.J. Jones. J. Am Soc Nephrol. 33(8):1546-1567, 2022. PDF
Building the phagocytic cup on an actin scaffold. M. Krendel, N.C. Gauthier NC. Curr Opin Cell Biol. 2022. doi: 10.1016/j.ceb.2022.102112. PDF
Focal segmental glomerulosclerosis and proteinuria associated with Myo1E mutations: novel variants and histological phenotype analysis. M. Krendel, S. Leh, M.E. Garone, A. Edwards-Richards, J.J. Lin, D. Brackman, P. Knappskog, A. Mikhailov. Pediatr Nephrol. 2022. doi: 10.1007/s00467-022-05634-x. PDF
ABI1-based expression signature predicts breast cancer metastasis and survival. A. Regua, C. Papp, A. Grageda, B.A. Porter, T. Caza, I Bichindaritz, M. Krendel, A. Sivapiragasam, G. Bratslavsky, V.A. Kuznetsov, L. Kotula. Mol Oncol. 2021. doi: 10.1002/1878-0261.13175.
Phagocytic 'teeth' and myosin-II 'jaw' power target constriction during phagocytosis. D. Vorselen, S.R. Barger, Y. Wang, W. Cai, J.A. Theriot, N.C. Gauthier, M. Krendel. Elife. 2021 Oct 28;10 PubMed Central PMCID: PMC8585483. PDF
Human myosin 1e tail but not motor domain replaces fission yeast Myo1 domains to support myosin-I function during endocytosis.
S.R. Barger, M.L. James, C.D. Pellenz, M. Krendel, V. Sirotkin. Exp Cell Res. 384(2):111625, 2019. PDF
Squeezing in a Meal: Myosin Functions in Phagocytosis.
S.R. Barger, N.C. Gauthier, M. Krendel. Trends Cell Biol. 30(2):157-167, 2020. PDF
Membrane-cytoskeleton mechanical feedback mediated by myosin-I controls phagocytic efficiency. S. R. Barger, N. S. Reilly, M. S. Shutova, Q. Li, P. Maiuri, M.S. Mooseker, R. A. Flavell, T. Svitkina, P. W. Oakes, M. Krendel, N. Gauthier. Nature Communications, 10(1):1249, 2019. PDF
Tail domains of myosin-1e regulate phosphatidylinositol signaling and F-actin polymerization at the ventral layer of podosomes. Y. Zhang, F. Cao, Y. Zhou, Z. Feng, B. Sit, M. Krendel, C. Yu. MBoC. 30(5):622-635, 2019.
Myosin-1E interacts with FAK proline rich region 1 to induce fibronectin-type matrix. J. B. Heim, E.J. Squirewell, A. Neu, G. Zocher, S. Sominidi-Damodaran, S.P. Wyles, E. Nikolova, N. Behrendt, D.M. Saunte, J. Lock-Andersen, K.S. Gaonkar, H. Yan, J.N. Sarkaria, M. Krendel, J. van Deursen, R. Sprangers, T. Stehle, R.T. Böttcher, J. Lee, T. Ordog, A. Meves. Proc Natl Acad Sci U S A. 114(15):3933-3938, 2017. PDF